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Look for the distinctive (but not pathognomonic) lewy bodies in dopaminergic (and other) neurons.
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There is more loss of cortex (and poorer outcome) over time if the patient gets classical antipsychotic agents, and less loss of cortex (and better outcome) than the untreated if the patient gets the newer agents (arch.
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*Â the quadriplegic patient who had brain electrodes implanted and was able to move an upper extremity prosthesis well enough to do daily activities and draw pictures: lancet 381: 557, 2013.